About Nolvadex: Nolvadex (Tamoxifen) is classified under the class of drugs known as selective estrogen receptor modulators or SERMs. This class of drugs have an estrogen antagonistic action on some sites in the body and have an opposite agonistic action on other sites. This partial agonist-antagonist effect and the selectivity of the antagonistic effect of Nolvadex has allowed its use in the treatment of breast cancer as well as the control of estrogen deficient symptoms in post menopausal women. Nolvadex has been found to be a miracle drug of sorts for patients suffering from breast cancer, and is generally used as adjuvant therapy in patients with estrogen receptor – positive breast cancer. It is indicated in patients who are pre-menopausal, though it has been found beneficial in post-menopausal patients. This is due to higher efficacy of aromatase inhibitors in this group of patients as compared to Nolvadex.

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How Nolvadex Works: Nolvadex contains Tamoxifen, a selective estrogen receptor modulator. It has a potent antagonistic action on estrogen receptors in breast cancer cells, blood vessels and some peripheral tissues. However it has a partial agonistic action on estrogen receptors in the uterus, bone, liver and pituitary gland. Nolvadex is a prodrug, and gets converted to active metabolites in the body. On entering the cell, Nolvadex (Tamoxifen) binds with the estrogen receptor in the cell causing changes to DNA synthesis and prevents the action of estrogen on these cells. This action results in the tumour cells entering a dormant phase. Hence though Nolvadex does not directly kill cancer cells, it causes them to stop proliferating. It has been found to be effective only when estrogen receptors (ER) are present in higher proportions in the tumour. These tumours also have better prognosis.
How To Take Nolvadex: Nolvadex has been approved for the treatment of both female and male breast cancer as an adjuvant drug administered after chemotherapy. It is to be used if the tumour is proven estrogen receptor positive on histochemical examination. Presence of aromatase inhibitors like Anastrazole has decreased the use of Nolvadex in post-menopausal patients, but the treatment cost with these drugs is significantly higher. Nolvadex has been approved for prevention of breast cancer in high risk patients as well as found to decrease the incidence of breast cancer in the remaining opposite breast. Nolvadex is also useful in the management of advanced metastatic breast cancer. Other conditions for which generic Nolvadex may be used are in the treatment of female infertility and anovulation, gynaecomastia which is enlargement of male breast tissue and in the treatment of premature puberty seen in McCune Albright syndrome. Nolvadex is available as oral tablets in the strengths of 10 mg and 20 mg.

The recommended dose for adjuvant therapy of breast cancer in patients is 20 mg/day taken as single daily dose. If need be, the dose may be escalated to a maximum of 40 mg/day taken as two divided doses of 20 mg each. For use in reduction of the risk of breast carcinoma in patients at high risk of developing it, or in patients with ductal carcinoma in situ (very early stage), order Nolvadex is administered at 20 mg/day as a single daily dose for a duration of 5 years. Nolvadex when used for any of these indications has not been found to be effective beyond a duration of 5 years.

Precautions And Side Effects Of Nolvadex: Nolvadex is not to be used in patients who have history of abnormal blood clotting in veins (Deep vein thrombosis) and in pregnant and lactating mothers. Nolvadex online should be used with caution in patients who are obese, heavy smokers and those with cardiac disease.

Common effects of Nolvadex are

  • hot flushes,
  • bleeding from the vagina,
  • pruritus vulvae,
  • weight gain,
  • fluid retention,
  • nausea,
  • headaches
  • and cramps.

More serious effects of Nolvadex are

  • hypercalcemia,
  • deep vein thrombosis,
  • hepatitis,
  • blood dyscrasias,
  • angioedema
  • and an increase in the risk of endometrial cancer.