About Tamoxifen: Tamoxifen, which is commonly marketed by the AstraZeneca Pharmaceutical Company (formerly Imperial Chemical Industries) is an estrogen receptor antagonist drug. Tamoxifen is marketed to the consumers under various trade names like Valodex, Nolvadex, and Istubal. In fact, this drug acts as an agonist in various tissues like the endometrial tissues and antagonist elsewhere. Thus, it is classified as a mixed drug. Tamoxifen is generally used as an anti-estrogen reception agent, and hence popularly used in the treatment of Breast Cancer. This drug is beneficial both in men as well as in women. Since, estrogen is required by the breast cancer affected cells to grow, stopping the growth can be one of the major benefits of using Tamoxifen for this therapy. The chemical formula of this drug is C26H29NO. This drug has a half life of 5 – 7 days in maximum, and is excreted after this via the fecal matter.
How Tamoxifen Works: Tamoxifen is a popular estrogen antagonistic drug, which has more cytostatic effect rather than cytosidal effect. Therefore, this drug actually does not kill the breast cancer cells, but it prevents the breast cancer cells from growing after the G0 or G1 stage. Tamoxifen binds with the estrogen receptors via the method of competitive binding, and hence prevents the actual estrogen molecules to bind to the receptors. Thus, Tamoxifen prevents the use of estrogen by the breast cells in the pre-cancerous stage to make use of the estrogen, and hence grow. This drug forms a nuclear complex in reality, which prevents the DNA synthesis any further. Tamoxifen online is non-steroidal in nature, and is a pro-drug. This drug has to be metabolized by the cytochrome P450 into the active form, which the individual needs for treatment. Since, the pro drug has very less affinity towards the estrogen receptors therefore it is converted into the active form of Afimoxifene and Endoxifen.
How To Take Tamoxifen: The dosage of Tamoxifen is based on the specific breast cancer situation it is being used for. For example, in case of metastatic breast cancer in male and female the dosage varies from 20 – 40 mg. But, if the dose that is being administered is more than 20 mg, then it should be broken down into equal doses. In case of men and women associated with Ductal Carcinoma along with breast cancer, then 20 mg of cheap Tamoxifen is administered orally for 5 – 6 years. In case of adjuvant breast cancer, male and female are administered with 10 mg of Tamoxifen 2 – 3 times regularly for two to three years.
Precautions And Side Effects Of Tamoxifen:
Tamoxifen shows 95 major and 199 moderate drug interactions approximately. The drugs with which Tamoxifen reacts majorly include drugs like
- diphenhydramine,
- phenylephrine,
- pseudoephedrine,
- Leflunomide,
- bupropion,
- Dolasetron,
- Clozapine,
- Amiodarone etc…
The drugs with which Tamoxifen has moderate interactions are drugs like
- Abarelix,
- doxepin,
- Dexamethasone,
- Adenosine,
- Palonosetron,
- Scopolamine, Aprepitant, etc…
This drug has some level of interaction with the consumption of alcohol too. If any of the interacting drugs is being taken by the patient, then the doctor must be immediately informed and the dosage should be changed if possible.
There are various side effects associated with the use of buy Tamoxifen. Though, these side effects have not been seen in major cases, but care must be taken to ensure that overdose of this drug is avoided.
The various symptoms of side effects of Tamoxifen include
- irregular vaginal bleeding,
- constipation,
- back pain,
- weight loss,
- cough,
- nausea,
- tendency to vomit etc…
There are allergic side effects of Tamoxifen, which includes symptoms like
- rash,
- fever,
- loss of appetite,
- blood pressure fluctuations,
- loss in body balance and coordination,
- swelling in various parts of the body etc…